Custom Peptides
Cayman Chemical DIchlorvos-d6 10mg
An internal standard for the quantification of dichlorvos by GC- or LC-MS
Cayman Chemical Betulonaldehyde 10mg
A pentacyclic triterpenoid; active against P. falciparum (IC50 = 3.36 UG/ml); cytotoxic to NCI H187 and Vero cells (IC50s = 19.23 and 17.09 UG/ml, respectively); reduces TPA-induced EAr edema in mice at 1 mg/ear; has also been used a precursor in the semisynthesis of C-2 and C-28 betulonic aldehyde derivatives
Cayman Chemical KIntensInhumntrIfluoro 10mg
A neurotensin ligand; binds to neurotensin receptors in HT-29 cells and mouse brain (Kis = 1,396 and 149.6 nM, respectively) but does not induce the accumulation of intracellular calcium in HT-29 cells (EC50 = >10,000 nM); induces histamine release in isolated rat peritoneal mast cells (EC50 = ~10 µM); induces vascular permeability in rats
Cayman Chemical CardIogenol ChydrochLRIde 10mg
Induces the differentiation of MHC-positive cardiomyocytes from embryonic stem cells with an EC50 value of 0.1 µM
Cayman Chemical ProstaglndIn Bx 10mg
PGBx is a mixture of oligomers of PGB1 with a molecular weight of 1,000-1,500. It has antioxidant and free radical trapping activity that was first studied in isolated mitochondria.{477} PGBx has anti-inflammatory and cytoprotective activity which may be attributed to inhibition of the 14 kDa sPLA2.{414,1188} At a dose of 1 mg/kg, PGBx significantly reduces the incidence of ulcers in rats.{414}
Cayman Chemical OlprInonhydrochlorIde 10mg
An inhibitor of PDE3 (IC50 = 0.35 μM for human cardiac enzyme); selective for PDE3 over PDE1 and PDE2 (IC50s = 150 and 100 μM, respectively); induces relaxation of precontracted isolated rabbit renal and carotid arterial rings (IC50s = 40 and 103 nM, respectively); reduces infarct size and improves cardiac function in a rat model of myocardial ischemia-reperfusion injury at 0.6 mg/kg twice per day; reduces cortical and striatal damage, as well as reduces injured cerebral tissue nitrotyrosine formation, apoptosis, and levels of iNOS, IL-1β, and ICAM-1 in a rat model of cerebral ischemia-reperfusion injury at 0.2 mg/kg; inhibits neutrophil infiltration into lung and inhibits increases in serum levels of TNF-α and IL-6 in a rat model of LPS-induced lung inflammation at 0.2 mg/kg
Cayman Chemical Asmadoln 10mg
A potent κ-opioid receptor agonist (IC50s = 5.6 and 1.2 nM for guinea pig and human receptors, respectively); is 501- and 498-fold selective for κ-opioid over μ- and δ-opioid receptors, respectively; is spasmolytic in isolated rat duodenum (IC50 = 4.2 μM) and inhibits spontaneous contractions of isolated rat uterus (IC50 = 12.7 μM); reduces joint damage in a rat model of CFA-induced arthritis; reduces the abdominal withdrawal reflex in a model of visceral pain induced by colonic distension in wild-type mice at 25 mg/kg
Cayman Chemical PramlIntIdeacetAT hydrAT 10mg
An amylin analog; stimulates cAMP production in HEK293 cells expressing human AMY1a, AMY2a, and AMY3a (EC50s = 0.35, 22.9, and 0.89 nM, respectively); inhibits human islet amyloid polypeptide fibrilization in a concentration-dependent manner; reduces brain levels of Aβ40 and increases spontaneous alternation in the Y-maze in the Tg2576 transgenic mouse model of Alzheimer's disease at 200 pg/kg
Cayman Chemical PseudoprotodIoscIn 10mg
A steroidal saponin; cytotoxic to A375, L929, and HeLa cancer cells (IC50s = 5.73, 5.09, and 3.32 µM, respectively); increases ERα nuclear accumulation in 3T3-L1 preadipocytes cultured in differentiation medium; inhibits LPS-induced increases in NF-κB activity in reporter assays using isolated mouse peritoneal macrophages and HUVECs; reduces atherosclerotic plaque area and inhibits increases in serum total cholesterol and triglyceride levels in ovariectomized ApoE-/- mice fed a high-cholesterol diet at 1, 2.5, and 5 mg/kg
Cayman Chemical EmIdeltIdeacetate 10mg
A synthetic nonapeptide sedative; increases EEG delta activity and induces orthodox slow-wave sleep in free-moving rabbits at 30 nmol/kg, i.v.; increases NREM and total sleep in free-moving rats
Cayman Chemical 20 S-ProtopnaxatrIol 10mg
An active ginsenoside metabolite; cytotoxic to HL-60 cancer cells (IC50 = 16 µM); inhibits the proliferation of HUVECs (EC50 = 6.64 UG/ml); blocks LPS-induced increases in the protein levels of COX-2 and iNOS and decreases LPS-induced NF-κB activity in RAW 264.7 cells from 1-20 µM
Cayman Chemical MEGXhydrochlorIde 10mg
An active metabolite of lidocaine; formed via N-deethylation of lidocaine by hepatic CYP3A4; topical administration reduces thrombus formation in a hamster model of laser-induced microvascular injury at 2% v/v; plasma levels following lidocaine administration have been used to monitor declining liver function in patients with cirrhosis
Cayman Chemical 6CarytetramthylrhodamIn 10mg
A fluorescent dye; ex/em = 543/572 nm, respectively; has commonly been used for the covalent labeling of oligonucleotides for DNA analysis; has been used in various DNA-protein binding studies, DNA FRET experiments, and as a standard reporter or quencher dye in RT-PCR
Cayman Chemical Arnba euchroma Shkalkn 10mg
A naphthoquinone and racemic mixture of alkannin and shikonin